|
KMID : 0882420080740020198
|
|
Korean Journal of Medicine
2008 Volume.74 No. 2 p.198 ~ p.202
|
|
|
A case of leptomeningeal metastasis from adenocarcinoma of the lung improved by treatment with Gefitinib
|
|
Yu Sung-Ken
Park Won-Jong
Chung Jin-Hong
Lee Kwan-Ho
Shin Kyeong-Cheol
Park Chan-Seo
Chin Hyun-Jung
|
|
|
Abstract
|
|
|
|
Leptomeningeal metastasis occurs in approximately 1% of patients with non-small cell lung cancer and this is an extremely serious complication. Without treatment, the median survival of patients is 4~6 weeks. The treatment options currently available are limited and achieve only modest results. Gefitinib was recently approved for the teatment of advanced/refractory non-small cell lung cancer. In addition, there have been case reports showing activity of gefitinib against brain metastasis in non-small cell lung cancer patients. However, there is limited data on the ability of gefitinib to cross the blood-brain barrier. We report the case of a patient with leptomeningeal metastasis from adenocarcinoma of the lung that had a dramatic response to gefitinib treatment.
|
|
|
KEYWORD
|
|
|
Leptomeningeal metastasis, Non-small cell lung cancer, Gefitinib
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|